文摘

从穿心莲pannicuolata Andrographaloide显著抑制H + K + atp酶和老鼠的PGE2水平增加

作者(年代):Vaibhav Mishra Haushila Prasad Pandey, Manoj Kumar Barthwal Gautam•帕立特,阿巴斯阿里马赫迪Vijai Santosh Kumar阿加沃拉克希

证据表明,andrographolide(美联社)变弱胃粘膜损伤;然而其机制尚未建立。本研究的目的是评估从穿心莲香穿心莲内酯、脱水穿心莲内酯gastroprotective机制的孤立。Andrographolide评估反对冷克制(CRU),阿司匹林(AS)、酒精(AL)和幽门结扎(PL)诱导大鼠胃溃疡模型。观察穿心莲内酯、脱水穿心莲内酯潜在抗肿瘤活性对CRU(62.5%)、(57.81%)、铝(72.41%)和PL(60.00%)诱导ulcermodels。标准的药物奥美拉唑(10毫克/公斤,订单。)对CRU的保护率为77.40%,对PLmodel项“57.08%和69.42%。硫糖铝,另一个标准药物(500毫克/公斤,订单。)显示,62.72%保护脊柱诱发溃疡模型。andrographolide显著降低游离酸度(50.42%)、总酸度(24.43%)和upregulatedmucin分泌分别由34.24%。此外,andrographolide抑制H + K + atp酶活性在体外分别与71.435µg /毫升的IC50与奥美拉唑的IC50值(30.24µg /毫升)确认anti-secretory活动。最终,穿心莲内酯、脱水穿心莲内酯anti-secretory机制介导显然通过与相应的H + K + atp酶抑制血浆胃泌激素水平下降,这是一种新型的财产在我们发现。 Andrographolide was found to possess anti-ulcerogenic activity which might be due to its anti-secretory activity and subsequent strengthening of the defensive mechanism.