摘要

亚麻木脂素浓缩液对烟酰胺-链脲佐菌素诱导的糖尿病高脂血症大鼠的降血脂作用

作者(年代):Nikhila Vengala

背景:亚麻籽已被证明对心血管疾病有多种益处。目的:评价亚麻木脂素浓缩液甲醇馏分(MF-FLC)对烟酰胺- stz致糖尿病高脂血症大鼠的降血脂作用。方法:雄性Wistar大鼠为研究对象。普那药学院的IAEC批准了这一提议。协议没有。CPCSEA / 01/14。采用烟酰胺- stz诱导大鼠糖尿病。糖尿病动物分为糖尿病动脉粥样硬化对照组、阿托伐他汀(10 mg/kg)、MF-FLC (200 mg/kg)、MF-FLC (400 mg/kg)、MF-FLC (800 mg/kg) 5组。糖尿病确诊后，给予大鼠胆固醇(4% w/w)和胆酸(1% w/w)治疗45天。在胆固醇治疗15 d后，两组给予阿托伐他汀和MF-FLC治疗30 d。 Non-diabetic atherosclerosis group received cholesterol-cholic acid treatment alone. The control group was given coconut oil as vehicle. Results: Treatment of MF-FLC (400 mg/kg) and atorvastatin (10 mg/kg) significantly reduced systolic blood pressure (p<0.01), diastolic blood pressure (p<0.01), mean arterial blood pressure (p<0.001) and left ventricular end diastolic pressure (p<0.001) whereas there was significant increase in Max dp/dt (p<0.001) and Min dp/dt (p<0.01) indicating the effect on cardiac contractility. These findings were confirmed in histopathology. MF-FLC (400 mg/kg) showed significant (p<0.01) reduction in the glucose level. MF-FLC (400 mg/kg) was found to be effective, increase in the dose (800 mg/kg) there showed a ceiling effect. Conclusion: The treatment with MF-FLC showed significant increase in the both max and min dp/dt. Atorvastatin (10 mg/kg) also showed significant increase in the both max and min dp/dt. This suggests that MF-FLC provides sufficient contractile reserve to ameliorate the detrimental effects of diabetes on cardiac contractility. MF-FLC had additional benefit of anti-hyperglycemic effect when compared to atorvastatin.