摘要

胆碱和一些营养油对大鼠肝脏和心脏组织诱导的NAFLD障碍的调节

作者(年代):Abd-El-Fattah ME, Dessouki AA, Emam AM, Abdel-Rahman HG和Kamal MM

非酒精性脂肪肝(NAFL)参与心血管危险的进展。像胆碱这样的增脂因子可以防止肝脏中过多的脂肪堆积。大蒜和洋葱含有大量的硫化合物。本研究旨在探讨胆碱、洋葱和大蒜油及两者的组合对高脂饮食大鼠的保护作用及其对肝脏和主动脉组织的影响。42只雄性白化大鼠随机分为6组;每只7只，饲养2个月。对照组;对照组，F组;脂肪饮食，f -胆碱组;含胆碱脂肪饲粮(3 gm/100 g饲粮)、F-OO、F-GO和F-mix组; fat diet and supplemented with onion oil (100 mg/Kg B.W), garlic oil (100 mg/Kg B.W) and combination of both oils, respectively. F-group significantly increased body weight, liver weight, serum lipid profile, hepatic and cardiac biomarkers, leptin hormone and tissue MDA level, while, significantly decreased serum HDL-C, total protein, albumin, TNO, adiponectin and tissue antioxidants compared to control group. Otherwise, the treated fat groups revealed significant improvement in all tested parameters compared to untreated fat group. In conclusion, onion and garlic oils combination induced marked hypolipidemic, antioxidant and anti-atherogenic impacts on hyperlipidemic rats.