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基于流变特性的醣脂类的霜制药和化妆品的应用程序

作者(年代):M。Misran Azrah阿卜杜勒阿齐兹

五乳化剂的乳化性质探讨了使用它们的流变学和比较。这些emulsifierA’年代拥有相同数量的碳烷基尾但有不同的组织结构。这种乳剂的流变学强烈依赖于分散液滴的平均粒度分布(Misni, 2002)。流动行为的这些基于醣脂类的霜是探索使用两种类型的流变学实验,即:稳定的剪切和振荡剪切实验。这些流变学propertiesAstrain和压力控制流变仪是用于此目的。剪切粘度进行扫描观察,我¨(我§)行为,在振荡进行扫描观察GA’(我·)和GA’’(我·)的行为。无论表面活性剂类型,检查剪切粘度依赖资料表明,根据剪切率,这里所有的乳剂检查显示混流的行为。Ashear稀释行为(非牛顿流)在低剪切率的指数衰减特征剪切粘度,而接近剪切速率独立流动行为(接近牛顿流)在高剪切率。剪切稀化度与表面活性剂浓度增加。我¬卡拉胶稳定乳剂也表现出较高的剪切粘度和显示零剪切粘度与DDM相比,10000年挂钩,SDS和Brij35P稳定乳剂在任何给定的剪切率。 As far as yield stress is concerned it depended highly on surfactant type and concentration. Compared to DDM, PEG 10,000, SDS and Brij35P stabilized emulsions -carrageenan stabilized emulsion exhibited higher magnitude of Yield Stress. As expected, yield stress increased with surfactant concentration. The combination of higher degree of shear thinning at low shear rates and higher yield stress exhibited by -carrageenan stabilized emulsions suggested that -carrageenan stabilized emulsions are more easily spread compared toDDM, PEG10,000, SDS and Brij35P stabilized emulsions.Oscillationmeasurementswithin the linear viscosity region suggested that -carrageenan stabilized emulsions exhibited higher values of both the G and G compared to emulsions stabilized by others over all frequencies ranges.Values ofGwas dominant over G over all frequency ranges, suggesting ease of spreading but low stability and shelf life. Both the moduli were frequency dependent and both followed exponentially increasing power law. The good news is that, at low frequencies, values of G’ could be increased gradually by increasing surfactant concentration. This in turn suggests that emulsions stability can be improved with surfactant concentration, with out compromising its spreading property. As far as flowmodel is concerned much like Brij 35p and SDS stabilized emulsions polysaccharide chain stabilized emulsions showed close toMaxwellian like fluid behavior, further, though these emulsions seemed relatively stable and that no imminent phase separation was observed.