摘要

药物配方中抗高血压药物和维生素的同时估计

作者(年代):Avdhoot J.Laud, Suhas Pednekar, Vikas V.Vaidya, Santosh S.Joshi, Sagar A.Parekh

建立了一种简便、快速、准确的反相高效液相色谱同时测定氢氯噻嗪含量的方法;叶酸;阿替洛尔;阿斯匹林;马来酸依那普利和阿托伐他汀钙。六种药物在Inertsil上分离;150毫米;4.6毫米;id . 5 μ m颗粒，C8柱。流动相为缓冲液:甲醇，采用二元梯度程序，流速为2.0mL min-1。 The bufferwas amixture of 0.01MSodiumDi-hydrogenOrtho-Phosphate (NaH2PO4); 0.01M of Di-Sodium Hydrogen Ortho-Phosphate (Na2HPO4) and 1.0 g of Sodium-Heptane Sulphonic acid in 1000mL purified water and pH adjusted to 2.6 with ortho-phosphoric acid. UV detection was performed at 215nm. The method was validated for linearity, accuracy, and precision parameters and these parameters were acceptable in the ranges 33.043µg mL-1 to 99.129µg mL-1 for Hydrochlorothiazide, 3.659µg mL-1 to 10.977µg mL-1 for folic acid, and 126.000µg mL-1 to 378.000µg mL-1 for Atenolol, 374.000µg mL-1 to 1122.000µg mL-1 for Aspirin, 10.000µg mL-1 to 40.000µg mL-1 for Enalapril, and 49.811µg mL-1 to 149.433µg mL-1 for Atorvastatin.